HAMP : hepcidin antimicrobial peptide

Description

The HAMP gene, located on chromosome 19, encodes the precursor protein for hepcidin, a key regulator of iron homeostasis. Hepcidin controls iron absorption from the gut and its release from macrophages and other cells. By binding to ferroportin, the sole known iron exporter in mammals, hepcidin promotes its internalization and degradation, leading to a decrease in circulating iron levels. This intricate regulation ensures that iron levels within the body remain within a safe and optimal range.

Associated Diseases

• Hereditary hemochromatosis (HH)
• Iron-refractory iron deficiency anemia (IRIDA)
• Juvenile hemochromatosis
• Anemia of chronic disease
• Hepatitis C
• Nonalcoholic fatty liver disease
• Cancer

Did you know?

Mutations in the HAMP gene can lead to iron overload disorders like hemochromatosis, while other mutations cause iron deficiency anemia. This highlights the gene‘s crucial role in maintaining a delicate balance of iron levels.