DGKE
Description
The DGKE gene provides instructions for making a protein called diacylglycerol kinase epsilon. This enzyme plays a crucial role in cell signaling by converting diacylglycerol (DAG) into phosphatidic acid (PA). DAG is a signaling molecule involved in various cellular processes, including cell growth, differentiation, and inflammation. DGKE, by regulating DAG levels, influences these processes, impacting cell behavior and potentially contributing to disease development.
Associated Diseases
- Neurodevelopmental disorders: DGKE mutations have been linked to intellectual disability, autism spectrum disorder, and epilepsy.
- Cancer: Alterations in DGKE expression and activity have been observed in several types of cancer, suggesting its potential role in tumorigenesis.
- Cardiovascular disease: DGKE has been implicated in heart function and may contribute to the development of cardiovascular disease.
Did you know?
DGKE belongs to a family of enzymes that play a vital role in regulating intracellular signaling pathways. These pathways are like complex communication networks within cells, coordinating essential processes.
