CFB

Description

The CFB gene provides instructions for making a protein called complement factor B. Complement factor B is part of the complement system, a critical part of the immune system. It helps to activate the alternative pathway of complement, which is a cascade of proteins that helps to destroy pathogens and clear debris from the body. This pathway is important for recognizing and destroying bacteria, viruses, and other harmful microorganisms. Variations in the CFB gene can affect the function of the complement system and contribute to a range of health conditions.

Associated Diseases

• Systemic lupus erythematosus (SLE)
• Hemolytic uremic syndrome (HUS)
• C3 glomerulopathy
• Atypical hemolytic uremic syndrome (aHUS)
• Meningococcal disease

Did you know?

Mutations in the CFB gene can lead to a deficiency in complement factor B, making individuals more susceptible to infections.