HELZ2
Description
The HELZ2 (helicase with zinc finger 2) is a protein-coding gene located on chromosome 20.
HELZ2 is an enzyme that breaks down RNA molecules. It uses energy from ATP to unwind complex RNA structures and then degrades them from the 3' end to the 5' end. HELZ2 prefers to cut RNA at pyrimidine bases (cytosine and thymine) rather than purine bases (adenine and guanine). HELZ2 can also act as a transcriptional coactivator, which means it helps other proteins turn genes on. It works with several nuclear receptors including PPARA, PPARG, THRA, THRB, and RXRA. HELZ2 interacts with PPARA and PPARG through their DNA-binding domains, boosting their activity. HELZ2 also directly interacts with THRAP3, and together they strengthen the activity of PPARG.
HELZ2 is also known as PDIP-1, PRIC285.
