HDAC6
Description
The HDAC6 (histone deacetylase 6) is a protein-coding gene located on chromosome X.
HDAC6 is a human enzyme with great potential as a therapeutic target for cancers and neurodegenerative disorders. It's a class II histone deacetylase with two catalytic domains. HDAC6 deacetylates histones, repressing transcription, and retracts the cilium before mitosis. It also deacetylates tubulin, promoting cancer cell metastasis.
HDAC6 deacetylates lysine residues on histone tails, contributing to epigenetic repression and regulating transcription, cell cycle progression, and development. HDAC6 forms complexes with other proteins to perform these functions. It also deacetylates non-histone proteins like CTTN, tubulin, and SQSTM1, playing crucial roles in cell motility, cilia disassembly, and autophagy. It promotes deacetylation of tubulin, impacting microtubule-dependent cell motility and cilia disassembly. HDAC6 also facilitates CTTN deacetylation, leading to actin polymerization and promoting autophagosome-lysosome fusion. HDAC6 is involved in the epigenetic regulation of ESR1 expression in breast cancer and promotes odontoblast differentiation. Beyond its deacetylase activity, HDAC6 is crucial for misfolded protein degradation, transporting them to aggresomes for clearance by autophagy. This protein interacts with various proteins like SIRT2, UBD, BBIP1, CBFA2T3, CYLD, DDIT3/CHOP, ZMYND15, F-actin, HDAC11, RIPOR2, AURKA, DYSF, TPPP, DYNLL1, ATP13A2, CCDC141, and IPO7, playing various roles in its function.
HDAC6 is also known as CPBHM, HD6, JM21, KDAC6, PPP1R90.
Associated Diseases
- Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia
- X-linked dominant chondrodysplasia, Chassaing-Lacombe type
