HCAR2
HCAR2: A Multifaceted Receptor with Implications in Health and Disease
Description:
HCAR2 (hydroxycarboxylic acid receptor 2) is a G protein-coupled receptor (GPCR) that binds various metabolites, including lactate, hydroxybutyrate, and phenylbutyrate. It is widely expressed throughout the body, particularly in the brain, heart, liver, and immune cells. HCAR2 plays crucial roles in regulating energy metabolism, inflammation, and cellular homeostasis.
Associated Diseases:
Dysregulation of HCAR2 signaling has been implicated in a range of diseases, including:
- Metabolic Syndrome: HCAR2 deficiency impairs glucose and lipid metabolism, contributing to insulin resistance and obesity.
- Cardiovascular Disease: Activation of HCAR2 promotes heart health by reducing inflammation and protecting against ischemia-reperfusion injury.
- Neurological Disorders: HCAR2 dysfunction is associated with neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
- Immune Disorders: HCAR2 modulates immune responses, influencing the severity of inflammatory conditions such as sepsis and rheumatoid arthritis.
Did you Know ?
- HCAR2 knockout mice exhibit a 50% reduction in lifespan, highlighting the critical role of this receptor in maintaining overall health.
