HACD2
Description
The HACD2 (3-hydroxyacyl-CoA dehydratase 2) is a protein-coding gene located on chromosome 3.
HACD2 is a protein encoded by the HACD2 gene in humans. It catalyzes the dehydration step in the conversion of long-chain fatty acids to very long-chain fatty acids. This process takes place in the endoplasmic reticulum, where HACD2 is localized. The protein encoded by this gene is essential for the production of various VLCFAs, which are precursors of membrane lipids and lipid mediators involved in multiple biological processes.
HACD2 catalyzes the dehydration step in the four-step cycle of very long-chain fatty acid (VLCFA) elongation. This process takes place in the endoplasmic reticulum and involves adding two carbons to the lipid chain per cycle. HACD2 converts the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, which is essential for the production of various VLCFAs. These VLCFAs serve as precursors for membrane lipids and lipid mediators, playing crucial roles in diverse biological processes.
HACD2 is also known as PTPLB.
Associated Diseases
- type 2 diabetes mellitus
- short stature due to GHSR deficiency
- mitochondrial disease
- fatty liver disease
