GZMH
Description
The GZMH (granzyme H) is a protein-coding gene located on chromosome 14.
Granzyme H is a protein that in humans is encoded by the GZMH gene.
Granzyme H is a cytotoxic chymotrypsin-like serine protease that exhibits a preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. It is likely crucial for target cell lysis during cell-mediated immune responses. Granzyme H plays a role in the antiviral response through direct cleavage of several proteins that are essential for viral replication.
GZMH is also known as CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2.
