GUCY2F
Description
The GUCY2F (guanylate cyclase 2F, retinal) is a protein-coding gene located on chromosome X.
GUCY2F (Retinal guanylyl cyclase 2) is a protein encoded by the GUCY2F gene in humans. It is predominantly found in photoreceptor cells of the retina and plays a crucial role in the visual signal transduction cascade. GUCY2F is thought to be involved in the resynthesis of cGMP after light activation, allowing the return to the dark state. Defects in this gene can lead to X-linked retinitis pigmentosa.
GUCY2F is responsible for producing cyclic GMP (cGMP) within the rods and cones of photoreceptor cells. This process is essential for phototransduction, as it facilitates the replenishment of cGMP levels. Additionally, GUCY2F may contribute to the movement of membrane-associated proteins to the outer segment membrane of photoreceptor cells.
GUCY2F is also known as CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2.
