GRIN3A
Description
The GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A) is a protein-coding gene located on chromosome 9.
The GRIN3A gene in humans encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, a type of glutamate-regulated ion channel essential for physiological and pathological processes in the central nervous system. This subunit shares high similarity with its counterpart in rats, exceeding 90% identity. Studies in knockout mice lacking this subunit suggest its involvement in the development of synaptic elements by modulating NMDA receptor activity.
The GRIN3A gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, a type of glutamate-gated ion channel. This subunit plays a critical role in the development of neural circuits by influencing synaptic refinement. It has reduced single-channel conductance, lower calcium permeability, and a diminished sensitivity to magnesium, compared to other NMDA receptor subunits. GRIN3A's function is mediated by glycine. During synaptic refinement, it restricts the maturation and growth of spines by competing with the interaction of GIT1 with ARHGEF7/beta-PIX, potentially reducing the local activation of RAC1 and influencing signaling pathways. GRIN3A may also participate in signaling mechanisms involving the protein phosphatase PP2CB.
GRIN3A is also known as GluN3A, NMDAR-L, NMDAR3A, NR3A.
Associated Diseases
- Parkinson disease
- Alzheimer disease
- depressive disorder
- major depressive disorder
- alcohol dependence
- bipolar disorder
- schizophrenia
- brain injury
