GRIN2C
Description
The GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C) is a protein-coding gene located on chromosome 17.
GRIN2C, the gene encoding Glutamate [NMDA] receptor subunit epsilon-3, produces a protein that is part of NMDA receptors, a class of ionotropic glutamate receptors. NMDA receptors are involved in long-term potentiation, which enhances synaptic transmission and is thought to underlie memory and learning. NMDA receptor channels are heteromers composed of the NMDAR1 (GRIN1) subunit and one or more of the four NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2C interacts with DLG4 and DLG3.
GRIN2C is a subunit of NMDA receptor complexes, which function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Activation of the channel requires glutamate binding to the epsilon subunit, glycine binding to the zeta subunit, and membrane depolarization to remove magnesium inhibition. The subunit composition influences glutamate sensitivity and channel kinetics. GRIN2C plays a role in regulating the balance of excitatory and inhibitory activity in prefrontal cortex pyramidal neurons. It contributes to the slow phase of excitatory postsynaptic currents, long-term synaptic potentiation, and learning.
GRIN2C is also known as GluN2C, NMDAR2C, NR2C.
Associated Diseases
- Parkinson disease
- Alzheimer disease
- depressive disorder
- major depressive disorder
- alcohol dependence
- schizophrenia
- bipolar disorder
- brain injury
