GPX6
Description
The GPX6 (glutathione peroxidase 6) is a protein-coding gene located on chromosome 6.
GPX6 is a gene encoding an enzyme, glutathione peroxidase 6 (GPx-6), that plays a crucial role in detoxifying hydrogen peroxide, a harmful reactive oxygen species. This enzyme belongs to the glutathione peroxidase family, known for their detoxification functions. GPX6 utilizes a selenocysteine residue at its active site, a unique amino acid encoded by the UGA codon, which usually signals translation termination. A specific stem-loop structure, the SECIS element, found within the 3' UTR of the gene, ensures the UGA codon is recognized as a selenocysteine codon rather than a stop signal. Interestingly, GPX6 expression is confined to embryos and the adult olfactory epithelium.
GPX6 plays a vital role in detoxifying hydrogen peroxide, a harmful reactive oxygen species. It achieves this by utilizing a selenocysteine residue at its active site, which is encoded by a UGA codon typically signaling translation termination. This unique codon recognition is facilitated by a specific stem-loop structure, the SECIS element, present in the 3' UTR of the gene.
GPX6 is also known as GPX5p, GPXP3, GPx-6, GSHPx-6, dJ1186N24, dJ1186N24.1.
Associated Diseases
- malignant epithelial tumor of ovary
- schizophrenia 15
- multiple sclerosis
- Phelan-McDermid syndrome
- schizophrenia
