GPR15
Description
The GPR15 (G protein-coupled receptor 15) is a protein-coding gene located on chromosome 3.
G protein-coupled receptor 15 (GPR15) is a protein encoded by the GPR15 gene in humans. GPR15 is a class A orphan G protein-coupled receptor (GPCR), a type of cell surface receptor that interacts with heterotrimeric guanine nucleotide-binding proteins (G proteins). The GPR15 gene is located on chromosome 3q11.2-q13.1. It is found in epithelial cells, synovial macrophages, endothelial cells, and lymphocytes, particularly T cells. Based on the mRNA sequence, GPR15 is predicted to have a molecular weight of 40.8 kDa. However, a 36 kDa band, composed of GPR15 and galactosyl ceramide, was detected in an epithelial tumor cell line (HT-29). Protein expression in lymphocytes is strongly associated with hypomethylation of the GPR15 gene.
GPR15 gene expression is high in the colonic mucosa, small bowel mucosa, liver, and spleen. Moderate expression is found in blood, lymph nodes, thymus, testis, and prostate. In peripheral blood, GPR15 is primarily found on T cells, especially CD4+ T helper cells, and less prominently on B cells.
GPR15 is also known as BOB.
Associated Diseases
- cancer
- isolated agammaglobulinemia
- common variable immunodeficiency
- T-B+ severe combined immunodeficiency due to JAK3 deficiency
- severe combined immunodeficiency due to IKK2 deficiency
- severe combined immunodeficiency due to CARD11 deficiency
- combined immunodeficiency due to ZAP70 deficiency
- Wiskott-Aldrich syndrome
- combined immunodeficiency with skin granulomas
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive
- severe combined immunodeficiency due to CTPS1 deficiency
- immunodeficiency 18
- combined immunodeficiency due to DOCK8 deficiency
- severe combined immunodeficiency due to CORO1A deficiency
- immunodeficiency 72 with autoinflammation
