GPR12


Description

The GPR12 (G protein-coupled receptor 12) is a protein-coding gene located on chromosome 13.

GPR12 is a protein encoded by the GPR12 gene in humans. Its function is currently unknown as it is an orphan receptor, meaning its natural binding partner is unidentified. Disrupting the GPR12 gene in mice leads to abnormal lipid levels and obesity.

GPR12 promotes the growth of neuron extensions (neurites) and prevents the inhibitory effects of myelin on neurons. It acts as a receptor with constant G(s) signaling activity, leading to an increase in cyclic AMP production.

GPR12 is also known as GPCR12, GPCR21, PPP1R84.

Associated Diseases


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