GPA33


Description

The GPA33 (glycoprotein A33) is a protein-coding gene located on chromosome 1.

GPA33 is a gene that codes for a protein called cell surface A33 antigen, which is found on the surface of cells. This protein is present in over 95% of human colon cancers. It has a specific structure with a signal sequence, glycosylation sites, and domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. This structure suggests it might interact with other cells. The protein has an extracellular region that extends outside the cell, a transmembrane domain that anchors it to the cell membrane, and an intracellular tail that interacts with the inside of the cell.

GPA33 is also known as A33.

Associated Diseases



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