GOLM1
Description
The GOLM1 (golgi membrane protein 1) is a protein-coding gene located on chromosome 9.
Golgi membrane protein 1 (GOLM1), also known as Golgi phosphoprotein 2 or Golgi membrane protein GP73, is a protein that in humans is encoded by the GOLM1 gene. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes protein synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this encoded protein has been observed to be upregulated in response to viral infection.
Golgi membrane protein 1 is overexpressed in prostate cancer and lung adenocarcinoma tissue. Blood levels of GP73 are higher in patients with liver cancer than in healthy individuals. In addition, levels were not significantly higher in patients with diseases other than liver disease. The current blood test used to screen for early tumors in people at high risk for liver cancer involves the alpha-fetoprotein (AFP).
GOLM1 is also known as C9orf155, GOLPH2, GP73, HEL46, PSEC0257, bA379P1.3.
