GOLGA8H
Description
The GOLGA8H (golgin A8 family member H) is a protein-coding gene located on chromosome 15.
Golgin subfamily A member 8H, also known as GOLGA8H, is a protein that in Homo sapiens is encoded by the GOLGA8H gene. Function of the GOLGA8H involves a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
== Gene ==
=== Aliases === The most common aliases for GOLGA8H are the following:
Golgin A8 Family Member H 2 3 5 or Member H 2 Golgi Autoantigen, Golgin Subfamily A, 6-Like 11 2 3 Golgin Subfamily A Member 8H 3 4 Golgin Subfamily A Member 8-Like Protein 1 3 GOLGA6L11
=== Prevalence and Location === GOLGA8H, when compared to many other genes, exists in many different places that span multiple chromosomes:. NCBI lists the gene’s location on the long (q) arm on Chromosome 15 in the q13.2 region, from 30,604,030 - 30,617,827 (13,798 nt in length)
In actuality, when running the FASTA protein sequence of GOLGA8H on BLAT (the BLAST-Like Alignment Tool), it is found to exist in 85 or 87 different locations (depending on an individual’s sex chromosomes). 81 copies of the protein exist on chromosome 15, one copy each on chromosomes 7, 9,10, and 12, and two copies on the Y chromosome Copies of GOLGA8H in Homo Sapiens
=== Neighborhood === It would be tedious and inefficient to list all gene neighborhoods for the 87 locations of GOLGA8H. Thus, here are surrounding genes of GOLGA8H on chromosome 15 in the q13.2 region listed on NCBI: Gene Neighborhood of GOLGA8H on Chromosome 15 q13.2 in Homo sapiens:
== Transcript == There are no isoforms of GOLGA8H.
== Multiple Sequence Alignment ==
=== Paralogs === A multiple sequence alignment (MSA) of GOLGA8H and its top seven paralogs was created using Clustal Omega [1]. [Appendix A] All eight genes from the Golgin Subfamily A Member 8 group were 632 amino acids in length [1]. All 632 amino acids of GOLGA8H and its top seven paralogs were analyzed and compared using Clustal Omega were analyzed and compared in an attempt to understand what makes Golgin Subfamily A Member 8H, GOLGA8H, a distinct entity. Two amino acids make GOLGA8H unique: Valine at amino acid 32 and Cysteine at amino acid 169. For all seven paralogs, the amino acid in position 32 is Isoleucine and the amino acid in position 169 is Arginine
== Protein == The predicted molecular weight of GOLGA8H, rounded down to three significant figures, is 71.3 kDa. This is a theoretical value; predicted molecular weights are merely based on the amino acids present in the protein.
GOLGA8H is also known as GOLGA6L11.
