GOLGA8A
Description
The GOLGA8A (golgin A8 family member A) is a protein-coding gene located on chromosome 15.
Golgin A8 family member A is a protein encoded by the GOLGA8A gene in humans. The Golgi apparatus, crucial for protein and lipid glycosylation and transport in the secretory pathway, comprises stacked, flattened membrane sacs called cisternae. Interactions between the Golgi and microtubules are considered vital for Golgi reorganization after fragmentation during cell division. Golgins are a protein family localized to the Golgi. This gene encodes a golgin resembling GOLGA2 in structure, hinting at shared functionality. Numerous similar copies of this gene reside on chromosome 15. Alternative splicing generates multiple transcript variants.
Plays a role in preserving the structural integrity of the Golgi apparatus.
GOLGA8A is also known as CFAP286, FAP286, GM88, GOLGA8B.
Associated Diseases
- refractive error
- carcinoma of liver and intrahepatic biliary tract
- progressive supranuclear palsy
- major depressive disorder
- amyotrophic lateral sclerosis
