GOLGA5
Description
The GOLGA5 (golgin A5) is a protein-coding gene located on chromosome 14.
Golgin subfamily A member 5 is a protein encoded by the GOLGA5 gene in humans. The Golgi apparatus, responsible for glycosylation and protein and lipid transport in the secretory pathway, is composed of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be crucial for Golgi reorganization after fragmentation during mitosis. GOLGA5 is a member of the golgin family of proteins that localize to the Golgi. This coiled-coil membrane protein is believed to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been identified in tumor tissues, resulting in chimeric sequences designated RET-II and PTC5.
GOLGA5 is also known as GOLIM5, RFG5, ret-II.
