GOLGA4
Description
The GOLGA4 (golgin A4) is a protein-coding gene located on chromosome 3.
GOLGA4 is a protein encoded by the GOLGA4 gene in humans. It is a member of the golgin family of proteins, which are localized to the Golgi apparatus, an organelle involved in protein and lipid modification and transport. GOLGA4 has been suggested to play a role in Rab6-regulated membrane-tethering events within the Golgi. The Golgi's interaction with microtubules is crucial for its reorganization after fragmentation during cell division. GOLGA4 has been shown to interact with the protein ARL1.
GOLGA4 is involved in vesicular trafficking at the Golgi apparatus, potentially contributing to the delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network via its interaction with MACF1. It also plays a role in endosome-to-Golgi trafficking.
GOLGA4 is also known as CRPF46, GCP2, GOLG, MU-RMS-40.18, p230.
Associated Diseases
- cancer
- Brugada syndrome
- familial atrial fibrillation
- ventricular fibrillation, paroxysmal familial, type 1
- arrhythmogenic right ventricular dysplasia 1
- cardiomyopathy, dilated, 2I
- familial sick sinus syndrome
- catecholaminergic polymorphic ventricular tachycardia
- ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome
- catecholaminergic polymorphic ventricular tachycardia 4
