GNAZ
Description
The GNAZ (G protein subunit alpha z) is a protein-coding gene located on chromosome 22.
The GNAZ gene encodes a protein called guanine nucleotide-binding protein G(z) subunit alpha. This protein belongs to a family of G proteins that participate in signal transduction within cells, independent of pertussis toxin. GNAZ may contribute to the regulation of ionic balance in the cochlear fluids. It has been observed to interact with proteins EYA2, RGS20, and RGS19.
Guanine nucleotide-binding proteins (G proteins) act as intermediaries in a variety of transmembrane signaling pathways, modulating or transmitting signals across cell membranes.
GNAZ is also known as HG1H, gz-alpha.
Associated Diseases
- esophageal cancer
- urinary bladder cancer
- urolithiasis
- lower urinary tract calculus
- thrombocytopenia 7
- Glanzmann thrombasthenia 1
- bleeding disorder, platelet-type, 24
