GMPS
Description
The GMPS (guanine monophosphate synthase) is a protein-coding gene located on chromosome 3.
Guanosine monophosphate synthetase (GMPS), encoded by the GMPS gene, is an enzyme that converts xanthosine monophosphate (XMP) to guanosine monophosphate (GMP). This reaction is part of the de novo synthesis of purine nucleotides, where IMP serves as a branch point metabolite for the synthesis of either guanine or adenine nucleotides. In this pathway, IMP dehydrogenase (IMPD1) catalyzes the oxidation of IMP to XMP, and then GMPS catalyzes the amination of XMP to GMP. GMPS requires glutamine and ATP as cofactors for this reaction. GMPS is a ligase enzyme that forms carbon-nitrogen bonds and utilizes glutamine as an amido-N-donor. It participates in purine metabolism and glutamate metabolism. Several structures of GMPS have been solved, including those from Escherichia coli, Pyrococcus Horikoshii, Thermoplasma acidophil, Homo sapiens, Thermus thermophilus, and Mycobacterium tuberculosis.
GMPS is also known as GATD7.
