GFI1B
Description
The GFI1B (growth factor independent 1B transcriptional repressor) is a protein-coding gene located on chromosome 9.
Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.
GFI1B is a key regulator of hematopoiesis, playing a crucial role in the development and differentiation of red blood cells (erythroid) and megakaryocytes (platelets). It acts as a transcriptional repressor or activator, depending on the specific gene and cell type. GFI1B interacts with other proteins to form a complex that silences genes involved in blood cell development, contributing to the control of hematopoietic differentiation. GFI1B is also involved in regulating cytokine signaling pathways, influencing the response of cells to growth factors and other signaling molecules. It can repress the expression of genes involved in apoptosis (programmed cell death), potentially contributing to the survival of certain blood cell types. GFI1B interacts with other key transcription factors, such as GATA1, to regulate the expression of genes important for erythroid development. This interaction forms a feedback loop, where GFI1B influences the expression of GATA1, and vice versa. Additionally, GFI1B binds to DNA and can alter histone methylation, a process that affects the accessibility of genes to transcription machinery. It participates in heterochromatin formation, a type of condensed DNA that is generally transcriptionally inactive. GFI1B interacts with a variety of proteins, including RCOR1, KDM1A, HDAC2, EHMT2, SUV39H1, ARIH2, and RUNX1T1, suggesting it plays a role in a complex network of regulatory pathways.
GFI1B is also known as BDPLT17, ZNF163B.
