GET4
Description
The GET4 (guided entry of tail-anchored proteins factor 4) is a protein-coding gene located on chromosome 7.
GET4 is a protein encoded by the GET4 gene in humans. It is involved in the delivery of proteins to the endoplasmic reticulum (ER) and the degradation of misfolded proteins.
The BAG6/BAT3 complex is a cytosolic protein quality control complex that maintains misfolded and hydrophobic proteins in a soluble state, assisting their delivery to the endoplasmic reticulum (ER) or promoting their degradation via the proteasome. It plays a crucial role in the post-translational delivery of tail-anchored/type II transmembrane proteins to the ER membrane, interacting with newly synthesized proteins and mediating their delivery to the ER with the help of SGTA and ASNA1. Misfolded proteins are ubiquitinated and sorted to the proteasome. The BAG6/BAT3 complex also acts as a sorting platform for mislocalized secretory pathway proteins, delivering them either to the proteasome or the ER. It is involved in ER-associated degradation (ERAD), ensuring retrotranslocated proteins are maintained in an unfolded state for proper delivery to the proteasome. The complex is composed of BAG6, UBL4A, and GET4/TRC35.
GET4 is also known as C7orf20, CDG2Y, CEE, CGI-20, TRC35.
