GEMIN6
Description
The GEMIN6 (gem nuclear organelle associated protein 6) is a protein-coding gene located on chromosome 2.
GEMIN6 is a protein encoded by the GEMIN6 gene in humans. It is a component of the SMN complex, which is found in the gems of Cajal bodies. This complex is essential for the assembly of snRNPs in the cytoplasm, which are involved in splicing pre-mRNAs. GEMIN6 interacts with GEMIN7.
The SMN complex, which includes GEMIN6, is crucial for the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. This complex plays a vital role in the splicing of cellular pre-mRNAs. Most snRNPs contain a set of Sm proteins that form a ring on the snRNA, forming the core snRNP. In the cytoplasm, these Sm proteins are initially inactive and trapped by a chaperone. The SMN complex then takes these trapped proteins and incorporates them into an intermediate. Once the snRNA binds to this intermediate, the SMN complex is released, allowing other Sm proteins to bind and complete the assembly of the core snRNP.
GEMIN6 is also known as -.
