NOD2

Description

The NOD2 gene, located on chromosome 16, encodes a protein that plays a crucial role in the innate immune system. NOD2, a pattern recognition receptor, detects specific bacterial components (muramyl dipeptide) and triggers downstream signaling pathways, leading to the activation of immune cells and the initiation of inflammatory responses. This intricate interplay between NOD2 and the immune system shapes our susceptibility to various diseases.

Associated Diseases

• Crohn‘s disease
• Inflammatory bowel disease (IBD)
• Blue rubber bleb nevus syndrome
• Sarcoidosis
• Tuberculosis
• Certain types of cancer
• Autoimmune disorders

Did you know?

Mutations in the NOD2 gene are the most common genetic risk factors for Crohn‘s disease, impacting about 20% of patients.