IL10RB

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Description

The IL10RB (interleukin 10 receptor subunit beta) is a protein-coding gene located on chromosome 21.

IL10RB (Interleukin 10 receptor, beta subunit) is a subunit for the interleukin-10 receptor. It is designated as CDw210b (cluster of differentiation w210b) and belongs to the cytokine receptor family. IL10RB is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins is required for IL10-induced signal transduction. The IL10RB gene, along with three other interferon receptor genes (IFNAR2, IFNAR1, and IFNGR2), forms a class II cytokine receptor gene cluster on chromosome 21.

IL10RB is also known as CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IBD25, IL-10R2, IL-10RB.

Associated Diseases

• Inflammatory bowel disease 25, early onset, autosomal recessive