IL10RA
Description
The IL10RA (interleukin 10 receptor subunit alpha) is a protein-coding gene located on chromosome 11.
Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its human gene. IL10RA has also been designated CDw210a (cluster of differentiation w210a). The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of myeloid progenitor cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Interleukin 10 receptor, alpha subunit has been shown to interact with: Interleukin 10 and Janus kinase 1.
IL10RA is a cell surface receptor for the cytokine IL10, playing a crucial role in IL10-mediated anti-inflammatory functions. It limits excessive tissue damage caused by inflammation. Upon binding to IL10, it triggers a conformational change in IL10RB, facilitating IL10RB's binding to IL10. This leads to the formation of a heterotetrameric complex consisting of two IL10RA and two IL10RB subunits. This complex then activates the kinases JAK1 and TYK2, which are constitutively associated with IL10RA and IL10RB, respectively. These kinases phosphorylate specific tyrosine residues within the intracellular domain of IL10RA, recruiting and subsequently phosphorylating STAT3. Phosphorylated STAT3 dimerizes, translocates to the nucleus, and activates the expression of anti-inflammatory genes. Moreover, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.
IL10RA is also known as CD210, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R.
