GAS2L1
Description
The GAS2L1 (growth arrest specific 2 like 1) is a protein-coding gene located on chromosome 22.
GAS2-like protein 1 is a protein that in humans is encoded by the GAS2L1 gene. The protein encoded by this gene, a member of the GAS2 family, is similar in sequence to the mouse protein Gas2, an actin-associated protein expressed at high levels in growth-arrested cells. Expression of the mouse Gas2 gene is negatively regulated by serum and growth factors. Three transcript variants encoding two different isoforms have been found for this gene.
GAS2L1 is also known as GAR22.
Associated Diseases
- type 2 diabetes mellitus
- partial chromosome Y deletion
- isolated congenital hypogonadotropic hypogonadism
- spermatogenic failures 50
- spermatogenic failure, X-linked, 2
- 46,XX ovotesticular disorder of sex development
- isochromosomy Yp
- 46,XY complete gonadal dysgenesis
- spermatogenic failure 63
- spermatogenic failure 25
- congenital bilateral absence of vas deferens
- male infertility with teratozoospermia due to single gene mutation
