GAS2
Description
The GAS2 (growth arrest specific 2) is a protein-coding gene located on chromosome 11.
GAS2, encoded by the GAS2 gene in humans, is a protein involved in regulating cell shape changes during apoptosis. It is a caspase-3 substrate, meaning it is cleaved by this enzyme during apoptosis. This cleavage triggers alterations in the actin cytoskeleton, leading to changes in cell shape. GAS2 can also influence cell sensitivity to apoptosis triggered by p53 by inhibiting calpain activity. Two different forms of GAS2 mRNA, produced by alternative splicing, encode the same protein.
GAS2 is a substrate for caspase-3, a key enzyme in apoptosis. Cleavage of GAS2 during apoptosis triggers significant rearrangements of the actin cytoskeleton, leading to dramatic changes in cell shape. This protein may also be involved in membrane ruffling.
GAS2 is also known as DFNB125, GAS-2.
