FZD3


FZD3: A Crucial Receptor in Wnt Signaling and Disease

Description

FZD3 (frizzled class 3) is a G protein-coupled receptor (GPCR) that plays a pivotal role in the Wnt signaling pathway, a critical pathway involved in embryonic development, cell proliferation, and differentiation. FZD3 binds to Wnt proteins, initiating a cascade of intracellular events that regulate gene expression and cellular processes.

Associated Diseases

FZD3 mutations or dysregulation have been implicated in various human diseases, including:

  • Colorectal cancer: FZD3 loss-of-function mutations are frequently observed in colorectal cancer, leading to reduced Wnt signaling and impaired cell growth control.
  • Hepatocellular carcinoma: FZD3 overexpression promotes liver cancer cell proliferation and metastasis.
  • Osteosarcoma: Aberrant FZD3 activation contributes to osteosarcoma development and progression.
  • Neurological disorders: FZD3 mutations have been associated with autism spectrum disorder and schizophrenia.
  • Congenital heart defects: Mutations in FZD3 can disrupt cardiac development, leading to heart defects such as atrial septal defects.

Did you Know ?

Approximately 15% of colorectal cancers harbor FZD3 mutations, highlighting the significant role of this gene in cancer development.


Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.