FZD10


FZD10: A Multifaceted Protein with Diverse Functions

Description

FZD10 is a member of the Frizzled family of G protein-coupled receptors (GPCRs) that play crucial roles in the Wnt signaling pathway, a key regulator of embryonic development and adult tissue homeostasis. It is a transmembrane protein with a large extracellular cysteine-rich domain, a seven-transmembrane domain, and an intracellular C-terminal tail.

Associated Diseases

Mutations or dysregulation of FZD10 have been associated with various human diseases, including:

  • Malignancies: FZD10 mutations have been found in several types of cancer, including breast, endometrial, and colon cancer.
  • Neurological disorders: Dysregulation of FZD10 has been implicated in Alzheimer's disease, Parkinson's disease, and schizophrenia.
  • Cardiovascular diseases: FZD10 plays a role in heart development and function, and its dysregulation has been linked to congenital heart defects and arrhythmias.
  • Skeletal disorders: Mutations in FZD10 have been identified in individuals with skeletal malformations and osteoporosis.

Did you Know ?

  • Only 10% of individuals with mutations in FZD10 develop any of the associated diseases, suggesting that genetic factors and environmental modifiers play a significant role in disease manifestation.


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