FUT5
Description
The FUT5 (fucosyltransferase 5) is a protein-coding gene located on chromosome 19.
Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT5 gene.
FUT5 catalyzes the transfer of L-fucose from a guanosine diphosphate-beta-L-fucose to the N-acetyl-beta-D-glucosamine (GlcNAc) of an N-acetyllactosamine unit (type 2 chain) of an oligosaccharide, or a glycoprotein- and a glycolipid-linked N-acetyllactosamine unit via an alpha (1,3) linkage. This enzyme participates in the surface expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens. FUT5 preferentially transfers fucose to the GlcNAc of an internal N-acetyllactosamine unit of a poly-N-acetyllactosamine chain acceptor substrate. It also catalyzes, to a lesser extent, the transfer of L-fucose to the GlcNAc of a type 1 (beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl) or H-type 1 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc) chain oligosaccharide via an alpha (1,4) linkage. FUT5 preferentially catalyzes sialylated type 2 oligosaccharide acceptors over neutral type 2 or H type 2 (alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc) oligosaccharide acceptors. Lactose-based structures are also acceptor substrates. {ECO:0000269|PubMed:14718375, ECO:0000269|PubMed:1740457, ECO:0000269|PubMed:17604274, ECO:0000269|PubMed:7721776, ECO:0000269|PubMed:9737988, ECO:0000269|PubMed:9737989}
FUT5 is also known as FUC-TV.
