FRS3
Description
The FRS3 (fibroblast growth factor receptor substrate 3) is a protein-coding gene located on chromosome 6.
FRS3, encoded by the FRS3 gene, is a protein that serves as a substrate for the fibroblast growth factor receptor. It is located in the peripheral plasma membrane and links FGF receptor stimulation to Ras activators.
FRS3 acts as a bridge between FGF and NGF receptors and downstream signaling pathways. It plays a role in activating MAP kinases and regulates ERK2 signaling by inhibiting its phosphorylation and entry into the nucleus.
FRS3 is also known as FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2.
