FNTA
Description
The FNTA (farnesyltransferase, CAAX box, subunit alpha) is a protein-coding gene located on chromosome 8.
FNTA is a human gene that encodes the alpha subunit of the enzyme protein farnesyltransferase/geranylgeranyltransferase type-1. These enzymes add either a farnesyl or geranylgeranyl group to a protein's cysteine residue, specifically at the C-terminal CAAX box. FNTA is a component of both CAAX geranylgeranyltransferase and CAAX farnesyltransferase, which are heterodimers with different beta subunits. This gene generates multiple transcript variants through alternative splicing, resulting in different isoforms. FNTA has been found to interact with TGF beta receptor 1.
FNTA is a crucial component of both the farnesyltransferase and geranylgeranyltransferase complexes. Its role involves transferring either a farnesyl or geranylgeranyl moiety from their respective diphosphate forms to a cysteine residue located at the fourth position from the C-terminus of several proteins. These target proteins contain a characteristic C-terminal sequence known as the CAAX box (Cys-aliphatic-aliphatic-X). Notably, FNTA's involvement in RAC1 prenylation and activation suggests a positive regulatory function in neuromuscular junction development, acting downstream of MUSK.
FNTA is also known as FPTA, PGGT1A, PTAR2.
Associated Diseases
- Hutchinson-Gilford progeria syndrome
- progeria
- ovarian cancer
- endometrial cancer
- breast cancer
- urinary bladder cancer
- lung cancer
