FN3K
Description
The FN3K (fructosamine 3 kinase) is a protein-coding gene located on chromosome 17.
FN3K is an enzyme that catalyzes the phosphorylation of fructosamines, which are formed by the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. This phosphorylation may initiate the metabolism of the modified amine and result in the deglycation of glycated proteins. FN3K is responsible for the formation of fructose 3-phosphate (F3P), a compound found in the lenses of diabetic rats. The spontaneous decomposition of F3P leads to the formation of 3-deoxyglucosone (3DG), which contributes to diabetic complications. Inhibiting FN3K has been shown to significantly reduce systemic 3DG in both normal and diabetic rats, suggesting that targeting FN3K could be a viable therapeutic strategy for diabetes-related diseases.
FN3K plays a critical role in protein deglycation by phosphorylating fructoselysine residues on glycated proteins, leading to the formation of fructoselysine-3 phosphate. This unstable adduct then decomposes under physiological conditions. FN3K is involved in intracellular deglycation within erythrocytes. It also contributes to the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, a process that is impaired by glycation. Furthermore, FN3K can phosphorylate psicosamines and ribulosamines. These functions are supported by evidence from UniProtKB:Q9ER35, PubMed:11016445, PubMed:11522682, PubMed:11975663, and PubMed:14633848.
FN3K is also known as -.
Associated Diseases
- cancer
- uridine-cytidineuria
- pentosuria
- proteinuria, chronic benign
- Dent disease
- primary hyperoxaluria type 3
- medullary sponge kidney
- plasma protein metabolism disease
- breast cancer
