FLYWCH1
Description
The FLYWCH1 (FLYWCH-type zinc finger 1) is a protein-coding gene located on chromosome 16.
FLYWCH1 acts as a transcription cofactor and negatively regulates the activation of transcription by CTNNB1. It may achieve this by competing with TCF4 for binding to CTNNB1. FLYWCH1 also plays a role in DNA damage response signaling. It binds to specific DNA sequences at peri-centromeric chromatin loci.
FLYWCH1 is also known as -.
Associated Diseases
- acroleukopathy, symmetric
- Dowling-Degos disease 1
- familial progressive hyperpigmentation
- linear atrophoderma of Moulin
- familial generalized lentiginosis
- dyschromatosis symmetrica hereditaria
- hyperpigmentation with or without hypopigmentation, familial progressive
- tufted angioma
- Alzheimer disease
- cancer
