FLJ35934
Description
Flj35934, also known as protein FAM151A, is a protein that plays a crucial role in various cellular processes. It is primarily located in the cytoplasm and the nucleus of cells. Flj35934 is involved in RNA metabolism, particularly in the processing and transport of messenger RNA (mRNA). It also participates in the regulation of cell growth, proliferation, and differentiation.
Structurally, Flj35934 is composed of several domains, including an RNA recognition motif (RRM) that enables it to bind to RNA molecules. It also contains a nuclear localization signal (NLS) that directs its movement into the nucleus.
Associated Diseases
Flj35934 has been implicated in several diseases, including:
- Cancer: Overexpression or mutations in Flj35934 have been associated with the development of certain types of cancer, such as breast cancer, lung cancer, and leukemia. Dysregulated Flj35934 can contribute to tumor growth, invasion, and metastasis.
- Neurodegenerative disorders: Flj35934 has been found to be downregulated in neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. Impaired RNA metabolism caused by Flj35934 deficiency may contribute to neuronal dysfunction and cell death.
- Developmental disorders: Mutations in Flj35934 have been linked to congenital disorders, such as intellectual disability and developmental delay. These mutations can disrupt the normal function of Flj35934 and affect brain development.
Did you Know ?
A study published in the journal "Nature Genetics" found that a specific variant in the Flj35934 gene was associated with an increased risk of developing breast cancer in women. Carriers of this variant were estimated to have a 30% higher risk of developing breast cancer compared to individuals without the variant.
