FHOD1
Description
The FHOD1 (formin homology 2 domain containing 1) is a protein-coding gene located on chromosome 16.
FHOD1 is a protein encoded by the FHOD1 gene in humans. It belongs to the formin/diaphanous protein family. While expressed ubiquitously, FHOD1 is particularly abundant in the spleen. The protein shares structural similarities with diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. Additionally, it possesses a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and multiple potential PKC and PKA phosphorylation sites. FHOD1 is predominantly found in the cytoplasm and is expressed in various human cell lines. It has been shown to interact with RAC1.
FHOD1 is also known as FHOS.
Associated Diseases
- Brugada syndrome
- familial atrial fibrillation
- His bundle tachycardia
- cardiomyopathy, dilated, 2I
- arrhythmogenic right ventricular dysplasia 1
- ventricular fibrillation, paroxysmal familial, type 1
