FGF4
Description
The FGF4 (fibroblast growth factor 4) is a protein-coding gene located on chromosome 11.
FGF4 is a protein encoded by the FGF4 gene in humans. It belongs to the fibroblast growth factor (FGF) family, known for their diverse biological activities, including cell growth, development, and repair. FGF4 exhibits oncogenic activity and is closely linked to FGF3 on chromosome 11. Their co-amplification is observed in various human tumors. Studies in mice suggest FGF4's role in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. During embryonic development, FGF4 plays a crucial role as a signaling molecule, impacting multiple developmental processes. Knockout studies in mice have revealed FGF4's contribution to the survival and growth of the inner cell mass during postimplantation, acting as an autocrine or paracrine ligand. FGFs produced in the apical ectodermal ridge (AER) are vital for proper forelimb and hindlimb growth.
FGF4 is also known as FGF-4, HBGF-4, HST, HST-1, HSTF-1, HSTF1, K-FGF, KFGF.
