FEM1A
Description
The FEM1A (fem-1 homolog A) is a protein-coding gene located on chromosome 19.
FEM1A is a protein in humans that is encoded by the FEM1A gene. It acts as a substrate-recognition component in the DesCEND pathway, which is responsible for targeting proteins for degradation through ubiquitination.
FEM1A acts as a substrate-recognition component within the Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, specifically in the DesCEND pathway. This pathway targets proteins for degradation by recognizing a C-degron motif located at the extreme C-terminus. The C-degron is typically a short sequence of less than ten residues and can be found in various protein forms, including full-length, truncated, or cleaved proteins. FEM1A within the CRL2 complex displays a preference for proteins ending with -Lys/Arg-Xaa-Arg or -Lys/Arg-Xaa-Xaa-Arg C-degrons, including proteins like SIL1 and OR51B2, leading to their ubiquitination and subsequent degradation. FEM1A is also implicated in promoting the ubiquitination and degradation of SLBP. Additionally, FEM1A is involved in the PGE2-EP4-mediated inhibition of inflammation in macrophages through interactions with NFKB1 and PTGER4. Conversely, FEM1A can promote inflammation in brain microglia via MAP2K4/MKK4-mediated signaling.
FEM1A is also known as EPRAP.
Associated Diseases
- Lynch syndrome
- hereditary mixed polyposis syndrome
- familial adenomatous polyposis 2
- gastric adenocarcinoma and proximal polyposis of the stomach
- Hirschsprung disease
- attenuated familial adenomatous polyposis
- AXIN2-related attenuated familial adenomatous polyposis
- ulcer disease
- hyperplastic polyposis syndrome
- colorectal cancer, susceptibility to, 3
