FBXO6
Description
The FBXO6 (F-box protein 6) is a protein-coding gene located on chromosome 1.
FBXO6 is a gene encoding a protein belonging to the F-box protein family. These proteins are characterized by an F-box motif, a component of the SCF (SKP1-cullin-F-box) ubiquitin protein ligase complex. FBXO6 falls into the Fbxs class and has a C-terminal region highly similar to rat NFB42, which might be involved in cell cycle regulation.
FBXO6, also known as F-box protein that recognizes sugar chains 2 (Fbx2) or F-box/G-domain protein 2, is a substrate-recognition component of certain SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes. It plays a critical role in the endoplasmic reticulum-associated degradation (ERAD) pathway for misfolded lumenal proteins. FBXO6 recognizes and binds to sugar chains on unfolded glycoproteins that have been retrotranslocated into the cytosol, promoting their ubiquitination and subsequent degradation. This recognition extends to both high-mannose and complex-type oligosaccharides, as well as sulfated glycans on denatured glycoproteins. FBXO6 is also involved in the DNA damage response. It specifically recognizes activated CHEK1 (phosphorylated on Ser-345), promoting its ubiquitination and degradation. This ubiquitination is crucial for preventing the accumulation of activated CHEK1 during S phase progression or when replication forks encounter temporary obstacles during normal DNA replication.
FBXO6 is also known as FBG2, FBS2, FBX6, Fbx6b.
Associated Diseases
- endometrial cancer
- ovarian cancer
- periodontal disorder
- nail-patella syndrome
- microphthalmia with limb anomalies
- breast cancer
- pachyonychia congenita
- cancer
