FANCD2OS
Description
The FANCD2OS (FANCD2 opposite strand) is a protein-coding gene located on chromosome 3.
The FANCD2OS gene is located on human chromosome 3, specifically at position p25.3 on the minus strand, spanning from 10,081,320 to 10,108,339 nucleotides. The primary transcript is 1105 nucleotides long and encodes a protein with 177 amino acids. The gene is situated on the strand opposite to FANCD2, located 5' to CYCSP11 and 3' to BRK1 and VHL genes.
The FANCD2OS gene exhibits alternative splicing, resulting in six different transcripts with variations in their 5' and 3' ends and exon usage. The most prevalent isoform is 1105 base pairs long.
The promoter region of the FANCD2OS gene, as predicted by the Genomatix El Dorado algorithm, extends from 10,108,742 to 10,108,009 base pairs. Promoters associated with this gene are found in various tissues, including B-lymphocytes, germ cells, muscle, neurons, and prostate.
The 5' untranslated region (UTR) sequence of the FANCD2OS gene exhibits conserved secondary structure between humans and gibbons. This sequence contains motifs recognized by RBMX, Ras, and Rab proteins, suggesting potential regulatory roles.
FANCD2OS is also known as C3orf24.
Associated Diseases
- Fanconi anemia
- Fanconi anemia complementation group D2
- ovarian cancer
- hereditary breast ovarian cancer syndrome
