FAM78B
Exploring FAM78B: A Vital Protein and its Role in Health and Disease
Description
FAM78B is a protein encoded by the FAM78B gene. This protein plays a crucial role in various cellular processes, including cell growth, proliferation, and differentiation. FAM78B is primarily localized to the cytoplasm, where it interacts with other proteins to form complexes involved in cellular signaling pathways.
Associated Diseases
Mutations in the FAM78B gene have been linked to several human diseases, including:
- Colorectal cancer: FAM78B loss-of-function mutations have been identified in a significant proportion of colorectal cancer cases. These mutations can promote tumor growth and metastasis.
- Hepatocellular carcinoma: Reduced FAM78B expression has been associated with increased risk and aggressiveness of hepatocellular carcinoma.
- Pancreatic cancer: Alterations in FAM78B expression levels have been linked to pancreatic cancer development and progression.
- Neurodegenerative diseases: Certain variants of the FAM78B gene have been associated with an increased risk of neurodegenerative diseases, such as Alzheimer‘s and Parkinson‘s disease.
Did you Know ?
Approximately 10-15% of colorectal cancers carry mutations in the FAM78B gene, making it one of the commonly mutated genes in this type of cancer.
