FAM74A4
FAM74A4: A Gene Linked to Alzheimer‘s Disease and More
Description
FAM74A4 (family with sequence similarity 74, member A4) is a gene that encodes a protein of the same name. This protein is involved in various cellular processes, including protein translation, RNA metabolism, and ribosome biogenesis.
Associated Diseases
Mutations in the FAM74A4 gene have been linked to several diseases, including:
- Alzheimer‘s disease (AD): FAM74A4 is one of the most common risk genes for late-onset Alzheimer‘s disease. Mutations in this gene can increase the risk of developing AD by up to 15%.
- Frontotemporal dementia (FTD): FAM74A4 mutations have also been associated with FTD, a degenerative brain disorder that affects the frontal and temporal lobes.
- Amyotrophic lateral sclerosis (ALS): Some studies suggest an association between FAM74A4 mutations and ALS, a progressive neurodegenerative disease that affects motor neurons.
Did you Know ?
- A study published in JAMA Neurology found that individuals with a rare mutation in the FAM74A4 gene had a 6-fold increased risk of developing Alzheimer‘s disease.
