FAM74A3
FAM74A3 Gene: An Overview
Description
FAM74A3 is a gene located on chromosome 20p13 in humans. It encodes a protein known as family with sequence similarity 74, member A3. This protein is involved in several cellular processes, including cell adhesion, migration, and proliferation.
Associated Diseases
Mutations in the FAM74A3 gene have been linked to several diseases, including:
- Breast cancer: FAM74A3 is a tumor suppressor gene, and mutations in this gene can increase the risk of developing breast cancer.
- Ovarian cancer: Mutations in FAM74A3 have also been associated with an increased risk of ovarian cancer.
- Other cancers: Mutations in FAM74A3 have been implicated in other types of cancer, such as lung cancer and prostate cancer.
- Intellectual disability: Mutations in FAM74A3 can cause intellectual disability, a condition characterized by significant impairments in cognitive abilities.
- Autism spectrum disorder: Mutations in FAM74A3 have been linked to autism spectrum disorder, a condition that affects social and communication skills.
Did you Know ?
According to a study published in the journal Breast Cancer Research, women with a particular mutation in the FAM74A3 gene have a 2.4-fold increased risk of developing breast cancer by age 50.
