FAM72C
Title: Fam72c: A Versatile Protein Involved in Multiple Biological Processes
Description:
Fam72c (Family with sequence similarity 72, member C) is a multifunctional protein with diverse roles in cellular processes. It belongs to the FAM72 family, which comprises proteins characterized by a conserved FAM72 domain. Fam72c is predominantly localized to the cytoplasm, where it exerts its functions in protein trafficking, membrane dynamics, and cell signaling.
Associated Diseases:
Dysregulation of Fam72c has been linked to several diseases, including:
1. Cancer: Fam72c plays a role in tumor suppression. Reduced expression of Fam72c has been observed in various cancer types, including lung, breast, and colon cancers. Its loss can promote tumor growth, invasion, and metastasis.
2. Neurological Disorders: Fam72c is involved in neuronal development and function. Mutations in the FAM72C gene have been implicated in neurodegenerative diseases such as Alzheimer‘s disease and amyotrophic lateral sclerosis (ALS).
3. Autoimmune Diseases: Fam72c has immunoregulatory functions. Dysregulation of Fam72c can contribute to the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE).
Did you Know ?
Studies have shown that:
- Over 80% of lung cancer patients have reduced Fam72c expression.
- Individuals with ALS carrying FAM72C mutations have a significantly shorter life expectancy than those without the mutations.
