FAM63B
FAM63B: A Gene with a Role in Multiple Diseases
Description
FAM63B is a gene located on chromosome 19 that encodes a protein known as family with sequence similarity 63 member B. This protein is involved in various cellular processes, including DNA repair, cell cycle regulation, and apoptosis.
Associated Diseases
Mutations in the FAM63B gene have been linked to several diseases, including:
- Fanconi Anemia: A rare genetic disorder characterized by bone marrow failure, physical abnormalities, and an increased risk of cancer.
- Ovarian Cancer: FAM63B mutations have been found in 15-20% of ovarian cancers, particularly in women with a family history of the disease.
- Breast Cancer: Studies have identified FAM63B as a potential susceptibility gene for breast cancer, although the association is not as strong as in ovarian cancer.
- Other Cancers: FAM63B mutations have also been implicated in other types of cancers, including lung cancer, colorectal cancer, and prostate cancer.
Did you Know ?
Approximately 1 in 50,000 individuals carries a FAM63B mutation that increases their risk of developing Fanconi Anemia.
