FAM25G
FAM25G: A Multifaceted Gene with a Role in Neurological Function and Disease
Description
FAM25G (Family with Sequence Similarity 25, Member G) is a gene located on chromosome 3p25. It encodes a protein called chromosome 3 protein 25 homolog G (CHRGP25G), which is highly expressed in the brain, particularly in neurons. CHRGP25G is a member of the FAM25 family of proteins, which are characterized by their conserved protein domains and involvement in various cellular processes.
Associated Diseases
Mutations in the FAM25G gene have been linked to a range of neurological disorders, including:
- Autism Spectrum Disorder (ASD): FAM25G mutations have been identified in a small percentage of individuals with ASD, suggesting a genetic contribution to the development of this complex condition.
- Intellectual Disability (ID): Similar to ASD, FAM25G mutations have been implicated in some cases of ID, particularly those with associated neurological features.
- Schizophrenia: Research has identified potential associations between FAM25G variations and the risk of schizophrenia, although further studies are needed to confirm these findings.
- Epilepsy: Certain FAM25G mutations have been found in patients with epilepsy, suggesting a role in the abnormal electrical activity of the brain that characterizes this condition.
Did you Know ?
According to a study published in the journal "Molecular Psychiatry," approximately 1% of individuals with ASD carry mutations in the FAM25G gene. This highlights the potential significance of FAM25G alterations in the etiology of ASD.
