FAM21C
Title: FAM21C: An Essential Gene with Far-Reaching Implications
Description
FAM21C is an essential gene that plays a crucial role in various cellular processes. It encodes a protein of the same name that is involved in the formation and maintenance of tight junctions, cellular structures that regulate the passage of molecules between cells. Mutations in the FAM21C gene have been linked to a range of diseases, including inflammatory bowel disease (IBD), Crohn's disease, and ulcerative colitis.
Associated Diseases
- Inflammatory bowel disease (IBD): IBD is a chronic inflammatory condition of the digestive tract that affects millions of people worldwide. Mutations in FAM21C have been identified as a significant risk factor for developing IBD, particularly Crohn's disease and ulcerative colitis.
- Crohn's disease: Crohn's disease is a type of IBD that causes inflammation and damage to the entire digestive tract, from the mouth to the anus. Studies have shown that mutations in FAM21C increase the risk of developing Crohn's disease by up to 4-fold.
- Ulcerative colitis: Ulcerative colitis is another type of IBD that affects only the large intestine and rectum. Mutations in FAM21C have also been associated with an increased risk of ulcerative colitis, but to a lesser extent than Crohn's disease.
Did you Know ?
Approximately 1 in 100 individuals of European descent carry a mutation in the FAM21C gene. This highlights the prevalence of this gene variant and its potential impact on human health.
